DIGITAL CLAMP ONE™ ELECTROPHYSIOLOGY CLAMPING AMPLIFIER
Digital Clamp One™ will provide neuroscientists with a new kind of platform for conducting ion channel experiments. The Digital Clamp One™ is capable of performing the following: 1) traditional voltage clamp and current clamp, 2) dynamic clamp that bridges two neurons, 3) single-electrode voltage clamp using a novel software-switched method, and 4) sophisticated control algorithms such as detect-then-trigger control and intermittent voltage clamp. All these capabilities in a single instrument opens up a world of new experiments possible in your lab.
Digital Clamp One™ is the first clamping amplifier available with fast digital feedback implemented with a front-end digital signal processor without relying on the host PC.
Digital signal processors have only recently become fast enough to fulfill this function in real time, and allow for digital processing of the fastest neuronal signals. Since the Digital Clamp One™ is an all-digital device, it has capabilities that are just not possible using standard analog feedback voltage clamps. These include Dynamic Clamping at a fast rate and Single Electrode Intermittent Clamping. The Digital Clamp One™ modules communicate through an Ethernet network. The number of headstages is scalable to satisfy the requirements for specific electrophysiological experiments. The Ethernet connector may be daisy chained to multiple Digital Clamp One™ units controlled from one host computer.
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Capabilities include
changing clamping modes dynamically, without transients, implementing sophisticated and/or model-based control algorithms, and creating artificial connections between neurons. This instrument and its headstages can implement the following functions:
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Conductance Clamping (Dynamic Clamping) that can:
•introduce an artificial conductance into a neuron and/or
• artificially connect two neurons - Voltage Clamping: Two Electrode, or Continuous or Intermittent Single Electrode
- Sophisticated Control Algorithms (such as detect then trigger intermittent voltage clamp)
- Current Clamping
- Digital Filtering (built-in digital filter bank)
- Whole Cell Preparations, or Single Channel Preparations
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Dynamic Mode Switching in Response to Real-Time Measurements
• voltage, current, or conductance clamp - Two or Four Headstage Models Available
- Ethernet Connection to the Computer at 100 MBPS
- Daisy chain to other Digital Clamp OneTMs Controlled from the Same Computer
Better Tools. better science.
Serving The Industry Since 2007.